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Lactose

Pharmaceutical lactose crushed/sieved ALFONOLAC® and lactose obtained by spray drying SPRAYLAC®

Lactose is a glucose and galactose disaccharide derived from the whey fraction of cow’s milk. Depending on the temperatures used for crystallization and drying of the lactose solution, this disaccharide can be obtained in either of two crystalline types: monohydrate or anhydrous type.

In addition, lactose disaccharide also has the ability to form two stable isomers known as alpha-lactose and beta-lactose. These two isomers differ in the orientation of the hydroxyl group in the glucose fragment. Lactose monohydrate crystals are mainly the alpha form, whereas anhydrous lactose is mainly the beta form (Zadow, 1984).

Crushed lactose ALFONOLAC®

During the grinding process, fine particles with sharp edges are formed, which improve the cohesive properties of the powder, which can be useful in granulation processes. Also, this type of lactose is characterized by a small particle size. Crushed varieties of alpha-lactose monohydrate ALFONOLAC® are used as a filler in dry and wet granulation processes.

Advantages:

• Good compressibility
• Good mixing performance
• High storage stability
• Stable quality from batch to batch

Application areas:

• Wet granulation
• Dry granulation
• Premixes
• Powder mixtures
• Fermentation
• Odor adsorbent

Types of crushed lactose ALFONOLAC®

ALFONOLAC® 70M/140M/150M/200M/300M/400M

SPRAYLAC®: lactose SPRAY DRIED.

Spray-dried lactose is an optimal mixture of crystalline alpha-lactose and amorphous lactose. The typical ratio of crystalline/amorphous lactose is about 85/15.

Physical characteristics:

• Loose, non-hygroscopic powder
• White to creamy white in color, without sediment and with excellent stability
• 10% solution (in boiling water) from transparent to almost colorless.

Advantages:

• High fluidity
• Better compressibility (excellent tablet strength with less compression force)
• Low hygroscopicity
• High degree of stability
• Fast disintegration time
• Filler for capsules and sachets